This single institution study involving 606 patients operated 2000-2012 examined the influence of the extent of lymphadenectomy on survival. The number of nodes resected was not related to all-cause mortality, even comparing the highest and lowest quartiles. The number of metastatic nodes and an increasing ratio of positive to negative nodes were e
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Esophagus - Cancer
July 23, 2015
This multicenter retrospective study evaluated the efficacy of salvage esophagectomy after definitive chemoradiotherapy compared to planned esophagectomy after induction chemoradiotherapy. Operative mortality was similarly high in both groups (8.4% vs 9.3%). Anastomotic leak was higher after salvage esophagectomy (17.2% vs 10.7%). 3-year survival
July 17, 2015
Retrospective study of 917 patients undergoing esophagectomy for squamous cell carcinoma at a single hospital in China. In the 7th version of the AJCC staging system for esophageal cancer, nodal stage (N stage) is based solely on the number of lymph node (LN) metastases.
July 14, 2015
This important consensus statement on definitions of postoperative complications after esophagectomy was developed by an international group of surgical experts. It should serve as a template for data collection and reporting for clinical reports and trials.
July 14, 2015
This small randomized trial evaluated the potential benefits of ghrelin, an anti-inflammatory agent, in reducing the SIRS response after esophagectomy. The ghrelin group had a reduced SIRS duration, lower CRP levels, and lower IL-6 levels compared to controls. Pulmonary complications were reduced in the ghrelin group, but other complication inciden
June 12, 2015
Outcomes of esophagectomy, including in-hospital mortality and length of stay (LOS), were compared between England (centralized care) and the US (no centralized care). Data for 2005-2010 included 7433 esophagectomies performed in 66 hospitals in England and 5858 esophagectomies performed in 775 hospitals in the US. Morality was greater in the US (5
June 11, 2015
This single institution retrospective analysis of esophagectomy or gastrectomy for GEJ cancer compared outcomes between groups who did and did not complete recommended 2 cycles of postoperative adjuvant chemotherapy. Of 110 pts who underwent perioperative chemotherapy, 67% completed postoperative adjuvant chemotherapy. Completion of 2 cycles or mor
May 17, 2015
In this population-based cohort study with 1044 patients who underwent esophagectomy for esophageal cancer between 1987 and 2010 in Sweden, the researchers found that a higher number of lymph nodes removed did not affect mortality in any specific stage.
February 13, 2015
This carefully prepared book is a wonderful compendium of scientific evidence regarding squamous cell cancer of the esophagus, written from a Japanese perspective.
January 10, 2015
The authors retrospectively analyzed pathologic response rates and their relation to the interval between completion of induction therapy and esophagectomy for esophageal cancer in 88 patients. Complete response rates increased from 12.5% to 40.9% among quartiles as the interval increased from <45 days to >63 days. There was no increase in mo